Pivotal Publications

Ben-Menachem E, Gabbai AA, Hufnagel A, Maia J, Almeida L, Soares-da-silva P. Eslicarbazepine acetate as adjunctive therapy in adult patients with partial epilepsy. Epilepsy Res. 2010;89(2-3):278-85.
http://www.ncbi.nlm.nih.gov/pubmed/20299189

Elger C, Halász P, Maia J, et al. Efficacy and safety of eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures: A randomized, double-blind, placebo-contolled, parallel-group phase III study. Epilepsia 2009;50:454-63.
http://www.ncbi.nlm.nih.gov/pubmed/19243424

Jacobson MP, Pazdera L, Bhatia P, Grinnell T, Chen H, Blum D, on behalf of the study 046 team. Efficacy and safety of conversion  to monotherapy with eslicarbazepine acetate in adults with uncontrolled partial-onset seizures: a historical-control phase III study. BMC Neurology. 2015;15:46. http://www.ncbi.nlm.nih.gov/pubmed/25880756

Sperling MR, Abou-Khalil B, Harvey J, et al. Eslicarbazepine acetate as adjunctive therapy in patients with uncontrolled partial-onset seizures: Results of a phase III, double-blind, randomized, placebo-controlled trial. Epilepsia. 2015;56(2):244-53.
http://www.ncbi.nlm.nih.gov/pubmed/25528898

Sperling MR, Harvey J, Grinnell T, Cheng H, Blum D. Efficacy and safety of conversion to monotherapy with eslicarbazepine acetate in adults with uncontrolled partial-onset seizures: A randomized historical-control phase III study based in North America. Epilepsia. 2015;56(4):546-55. http://www.ncbi.nlm.nih.gov/pubmed/25689448

Kerwin EM, Gotfried MH, Lawrence D, et al. Efficacy and tolerability of indacaterol 75 μg once daily in patients aged ≥40 years with chronic obstructive pulmonary disease: results from 2 double-blind, placebo-controlled 12-week studies. Clin Ther. 2011;33(12):1974-1984.
https://www.ncbi.nlm.nih.gov/pubmed/22177371

Baumgartner RA, Hanania NA, Calhoun WJ, Sahn SA, Sciarappa K, Hanrahan JP. Nebulized arformoterol in patients with COPD: a 12-week, multicenter, randomized, double-blind, double-dummy, placebo- and active-controlled trial. Clin Ther. 2007;29(2):261-278.
http://www.ncbi.nlm.nih.gov/pubmed/17472819

Donohue JF, Hanania NA, Sciarappa KA, et al. Arformoterol and salmeterol in the treatment of chronic obstructive pulmonary disease: a one year evaluation of safety and tolerance. Ther Adv Resp Dis. 2008;2(2):37-48.
http://www.ncbi.nlm.nih.gov/pubmed/19124357

Hanania NA, Donahue JF, Nelson H, et al. The safety and efficacy of arformoterol and formoterol in COPD. COPD. 2010;7(1):17-31.
http://www.ncbi.nlm.nih.gov/pubmed/20214460

Hanrahan JP, Hanania NA, Calhoun WJ, Sahn SA, Sciarappa K, Baumgartner RA.  Effect of nebulized arformoterol on airway function in COPD:  results from two randomized trials. COPD. 2008;5(1):25-34.
http://www.ncbi.nlm.nih.gov/pubmed/18259972

Loebel A, Cucchiaro J, Sarma K, et al.  Efficacy and safety of lurasidone 80 mg/day and 160 mg/day in the treatment of schizophrenia: A randomized, double-blind, placebo- and active-controlled trial.  Schizophr Res. 2013;145(1-3):101-9.
http://www.ncbi.nlm.nih.gov/pubmed/23415311

Loebel A, Cucchiaro J, Silva R, et al. Lurasidone monotherapy in the treatment of bipolar I depression: a randomized, double-blind, placebo-controlled study. Am J Psychiatry. 2014;171(2):160-8.
http://www.ncbi.nlm.nih.gov/pubmed/24170180

Loebel A, Cucchiaro J, Silva R, et al. Lurasidone as adjunctive therapy with lithium or valproate for the treatment of bipolar I depression: a randomized, double-blind, placebo-controlled study. Am J Psychiatry. 2014;171(2):169-77.
http://www.ncbi.nlm.nih.gov/pubmed/24170221

Meltzer HY, Cucchiaro J, Silva R, et al. Lurasidone in the treatment of schizophrenia: a randomized, double-blind, placebo- and olanzapine-controlled study. Am J Psychiatry. 2011;168(9):957-67.
http://www.ncbi.nlm.nih.gov/pubmed/21676992

Nakamura M, Ogasa M, Guarino J, et al. Lurasidone in the treatment of acute schizophrenia: a double-blind, placebo-controlled trial. J Clin Psychiatry. 2009;70(6):829-36.
http://www.ncbi.nlm.nih.gov/pubmed/19497249

Nasrallah HA, Silva R, Phillips D, et al.  Lurasidone for the treatment of acutely psychotic patients with schizophrenia: A 6-week, randomized, placebo-controlled study. J Psychiatr Res. 2013;47(5):670-77.
http://www.ncbi.nlm.nih.gov/pubmed/23421963

Ogasa M, Kimura T, Nakamura M, Guarino J. Lurasidone in the treatment of schizophrenia: a 6‑week, placebo‑controlled study. Psychopharmacology (Berl). 2013;225(3):519-30.
http://www.ncbi.nlm.nih.gov/pubmed/22903391

Kerwin E, Donohue JF, Goodin T, Tosiello R, Wheeler A, Ferguson GT. Efficacy and safety of glycopyrrolate/eFlow® CS (nebulized glycopyrrolate) in moderate-to-very-severe COPD: results from the Glycopyrrolate for Obstructive Lung Disease via Electronic Nebulizer (GOLDEN) 3 and 4 randomized controlled trials [published online ahead of print July 19, 2017]. Respir Med.
https://doi.org/10.1016/j.rmed.2017.07.011

Ferguson GT, Goodin T, Tosiello R, Wheeler A, Kerwin E. Long-term safety of glycopyrrolate/eFlow® CS in moderate-to-very-severe COPD: results from the Glycopyrrolate for Obstructive Lung Disease via Electronic Nebulizer (GOLDEN) 5 randomized study [published online ahead of print August 24, 2017]. Respir Med.
http://dx.doi.org/10.1016/j.rmed.2017.08.020

Erman MK, Zammit G, Rubens R, et al. A polysomnographic placebo-controlled evaluation of the efficacy and safety of eszopiclone relative to placebo and zolpidem in the treatment of primary insomnia. J Clin Sleep Med. 2008;4(3):229-34.
http://www.ncbi.nlm.nih.gov/pubmed/18595435

Krystal AD, Walsh JK, Laska E, et al. Sustained efficacy of eszopiclone over 6 months of nightly treatment: results of a randomized, double-blind, placebo-controlled study in adults with chronic insomnia. Sleep. 2003;26(7):793-9.
http://www.ncbi.nlm.nih.gov/pubmed/14655910

McCall WV, Erman M, Krystal AD, et al. A polysomnography study of eszopiclone in elderly patients with insomnia. Curr Med Res Opin. 2006;22(9):1633-42.
http://www.ncbi.nlm.nih.gov/pubmed/16968566

Rosenberg R, Caron J, Roth T, Amato D. An assessment of the efficacy and safety of eszopiclone in the treatment of transient insomnia in healthy adults. Sleep Med. 2005;6(1):15-22.
http://www.ncbi.nlm.nih.gov/pubmed/15680290

Scharf M, Erman M, Rosenberg R, et al. A 2-week efficacy and safety study of eszopiclone in elderly patients with primary insomnia. Sleep. 2005;28(6):720-7.
http://www.ncbi.nlm.nih.gov/pubmed/16477959

Zammit GK, McNabb LJ, Caron J, Amato DA, Roth T. Efficacy and safety of eszopiclone across 6-weeks of treatment for primary insomnia. Curr Med Res Opin. 2004;20(12):1979-91.
http://www.ncbi.nlm.nih.gov/pubmed/15701215

Kerwin E, Siler TM, Korenblat P, et al. Efficacy and safety of twice-daily glycopyrrolate versus placebo in patients with COPD: the GEM2 study. Chronic Obstr Pulm Dis (Miami). 2016; 3(2): 549-559.
http://doi.org/10.15326/jcopdf.3.2.2015.0157

Laforce C, Feldman G, Spangenthal S, et al. Efficacy and safety of twice-daily glycopyrrolate in patients with stable, symptomatic COPD with moderate-to-severe airflow limitation: the GEM1 study. Int J Chron Obstruct Pulmon Dis. 2016;11:1233-43.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907493/

Mahler DA, Kerwin E, Ayers T, et al. FLIGHT1 and FLIGHT2: Efficacy and Safety of QVA149 (Indacaterol/Glycopyrrolate) versus Its Monocomponents and Placebo in Patients with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2015;192(9):1068-79.
https://www.ncbi.nlm.nih.gov/pubmed/26177074

Berger WE, Milgrom H, Skoner DP, et al. Evaluation of levalbuterol metered dose inhaler in pediatric patients with asthma: a double-blind, randomized, placebo- and active-controlled trial. Curr Med Res Opin. 2006;22(6):1217-26.
http://www.ncbi.nlm.nih.gov/pubmed/16846555